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Design\u002Fmethodology\u002Fapproach The authors utilized the hierarchical regression approach to check the effects of three cultural variables – the individualism measure, taken from Hofstede’s six-dimension national culture index, and the measure of cultural tightness, based on the three tightness–looseness indexes calculated by Irem Uz (2015) and their interaction – on the changes in the prevalence rate (ΔPR) and crude mortality rate (ΔCMR) and case fatality rate (CFR) while controlling for the stringency of government responses to COVID-19, median age and population density. Findings Significant relationships were found between cultural variables and national performance in slowing the spread of the coronavirus, measured by ΔPR, ΔCMR and CFR. After controlling for the stringency of government responses, median age and population density, the authors found that cultural tightness and individualism as well as their interactions remain to be pivotal. Loose and individualistic cultures led to faster increases in PR and CMR and higher CFR. A four-quadrant conceptual framework is developed to categorize and discuss the national differences. Originality\u002Fvalue The paper integrated two constructs – cultural tightness–looseness and individualism–collectivism – to form a theoretical lens to guide the authors’ analyses while using the real-time COVID-19 data as a natural experiment for theorizing and testing. This study’s findings have significant policy implications in government responses, strategic planning, cultural adaptability and policy implementations for the world’s continuous battle against the pandemic.",[11,12,13],"Cao, Cong","Li, Ning","Liu, Li",[15,16,17],"0000-0002-3407-7837","0000-0002-2699-4563","0000-0002-7119-010X",2020,"https:\u002F\u002Fdoi.org\u002F10.1108\u002Fijssp-07-2020-0334","W3091474810","International Journal of Sociology and Social Policy",null,[24,25,26,27,28,29,30,31,32,33,34,35,36,37],"Hofstede's cultural dimensions theory","Individualism","Collectivism","Population","Conceptual framework","Uncertainty avoidance","Sociology","Social psychology","Demographic economics","Psychology","Demography","Political science","Economics","Social 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